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    • 专利摘要:
    The present invention relates to compositions for deodorizing and cleaning, particularly solid compositions in the form of effervescent tablets which can be reconstituted in water to obtain solutions for cleaning and deodorizing. The compositions comprise one or more strains of Bacillus subtilis, one or more surfactants, one or more fragrances, one or more descaling agents and one or more effervescent agents. The invention further relates to a kit comprising such tablets, as well as to methods for obtaining cleaning and deodorizing tablets and solutions and their use for cleaning and deodorizing.
    公开号:BE1021640B1
    申请号:E2013/0186
    申请日:2013-03-20
    公开日:2015-12-22
    发明作者:Abdelhamid Jabrane
    申请人:Pollet S.A.；
    IPC主号:
    专利说明:

    COMPOSITIONS AND METHODS FOR CLEANING AND DEODORIZING FIELD OF THE INVENTION
    The present invention relates to compositions for deodorizing and cleaning, in particular solid compositions in the form of effervescent tablets that can be reconstituted in water to provide solutions for deodorizing and cleaning, and a kit comprising such tablets. The present invention further relates to methods for obtaining tablets and cleaning and deodorizing solutions and their use for cleaning and deodorizing.
    BACKGROUND OF THE INVENTION
    Odor control is a major challenge, for example in sanitary facilities, such as urinals, toilet bowls and waste disposal facilities, such as drains, drains and trash cans or storage and disposal sites. 'waste disposal. Odors come from a wide variety of compounds and substances that are both organic and inorganic. Bad odors usually come from volatile molecules containing a wide variety of functional groups, such as sulphides, mercaptans, thioesters, acids, esters, amines, aldehydes and ketones, each associated with characteristic odors. A significant fraction of bad odors are generated by microbial fermentation processes, which results in the generation and release of such volatile components.
    Numerous methods and products exist to date for controlling odors, for example those described in EP 1,213,344, DE 196 37 606, and US 6,440,926. Many of the available products, however, are not very practical to use and it may be necessary to combine multiple different products for sequential use to effectively control odors. In addition, for the most part, the available products are based on the use of biocides, for example, to eliminate odor-producing micro-organisms, which results in applications that are not environmentally friendly. In addition, often the products available only treat the consequences of unpleasant odors by masking odors, instead of eliminating the source of unpleasant odors.
    In view of this, there remains a need in the art to provide improved processes and products to control and eliminate bad odors. An object of the invention is to provide such products and methods, which overcome at least part of the shortcomings of existing products and processes.
    SUMMARY OF THE INVENTION
    The present invention relates to methods and products for controlling and eliminating bad odors. The products and processes according to the invention advantageously combine the aspects of deodorization as well as cleaning by using compositions combining odor-eliminating constituents as well as cleaning components.
    In one aspect, the present invention provides a tablet for deodorizing and cleaning comprising: (i) one or more Bacillus subtilis strains; (ii) one or more surfactants; (iii) one or more fragrances; (iv) one or more descaling agents; and (v) one or more effervescent agents.
    The inventors were surprised to discover that the components listed above can be combined into a single solid composition such as a tablet. It was previously thought that the components listed above could not be combined in a single solid dosage form, such as a tablet, particularly because the constituents are concentrated in a solid dosage form, relative to a reconstituted liquid dosage form. In addition, the components listed above unexpectedly act synergistically to deodorize and clean. Advantageously, such a solid dosage form, in particular a tablet, is effervescent and can be reconstituted easily and rapidly in water to obtain a liquid cleaning and deodorizing solution. The solid dosage form advantageously makes it possible to formulate the cleaning and deodorizing product according to the invention so that it occupies a minimum volume, which is thus profitable with regard to transport costs. Furthermore, while the solid dosage form according to the invention is preferably intended to be reconstituted in a predetermined amount of water, higher or lower concentrations can be obtained, thus advantageously increasing the flexibility of use of the solid dosage form according to the invention, for example to treat heavily contaminated areas compared to weakly contaminated areas. Therefore, the solid dosage form according to the invention is characterized by its extreme ease of use, its flexibility of use and its unprecedented quality of use, which rely on the unexpected synergistic action of the constituents as well as on the advantageous combination of cleaning and deodorizing constituents.
    In one embodiment, the tablet comprises between 106 and 1011 cfu of said one or more Bacillus subtilis strains, preferably 109 cfu of said one or more Bacillus subtilis strains. The tablet preferably has the size, dimensions and / or weight as described in the text. Therefore, in one embodiment, the tablet, preferably a 4 g tablet, comprises between 10 and 1011 cfu of said one or more Bacillus subtilis strains, preferably 109 cfu of said one or more Bacillus subtilis strains. Alternatively, in one embodiment, the tablet comprises between 10 and 1011 cfu of said one or more Bacillus subtilis strains, preferably 109 cfu of said one or more Bacillus subtilis strains per 4 g of solid dosage form. The inventors have discovered that the Bacillus strains as described herein are effective in occupying the treated space and thus prevent the infiltration, establishment and / or propagation of harmful microorganisms that produce components responsible for the generation of bad smells. On the other hand, the Bacillus strains as described herein produce various enzymes that are capable of attacking the source of the bad odor by enzymatically (ie, digesting) the compounds at the site. origin of the bad smell.
    In another embodiment, said one or more fragrances are based on mint, preferably DL-menthol, delta p-mentha-1 (6), 8-dien-2-one, p-menthan- 3-one and Rp-Mentha-1,8 diene. In one embodiment, the tablet comprises between 2 and 10% by weight of said one or more fragrances, preferably 7% by weight of said one or more fragrances. The inventors were surprised, and contrary to their expectations, to discover that the fragrance as described herein can be provided in the tablet according to the invention in such high concentrations. It was not expected, in fact, that liquid fragrances could be provided in concentrations greater than 2% by weight in tablets. The provision of a fragrance in the solid dosage form according to the invention, such as a tablet, contributes advantageously and synergistically to eliminate and control bad smells. A fragrance also has a very fast, almost instantaneous effect on the control of odors.
    In another embodiment, said one or more surfactants are an alkyl sulfate, preferably sodium lauryl sulfate. In one embodiment, the tablet comprises between 0.1 and 5% by weight of said one or more surfactants, preferably 4% by weight of said one or more surfactants. The provision of a surfactant in the solid dosage form according to the invention, such as a tablet, advantageously contributes to the cleaning function, such as degreasing, of compositions as described herein.
    According to another embodiment, said one or more descaling agents are an organic acid, preferably citric acid. In one embodiment, the tablet comprises between 1 and 50% by weight of said one or more descaling agents, preferably 40% by weight of said one or more descaling agents. The provision of a descaling agent in the solid dosage form according to the invention, such as a tablet, advantageously and synergistically contributes to eliminating and controlling odors and contributes further to the cleaning function, such as the elimination of solid deposits resulting for example from calcification. Without wishing to confine ourselves to the theory, we believe that the compounds that cause bad odors can be trapped in or combined with such solid deposits and that the application of a descaling agent in addition to descaling can also allow to improve the effectiveness of the residual odor eliminating constituents in the solid dosage compositions as described herein.
    In another embodiment, said one or more effervescent agents are a mixture that releases carbon dioxide when in contact with water, preferably a mixture comprising citric acid and sodium bicarbonate. In one embodiment, the tablet comprises between 40 and 95% by weight of said one or more effervescent agents, preferably 65% by weight of said one or more effervescent agents. The use of effervescent agents advantageously allows very rapid reconstitution of the solid dosage form, such as a tablet, as described herein. Furthermore, after dissolution, minimal or no manipulation is sufficient to ensure proper mixing of the constituents of the solid dosage compositions, particularly tablets, as described herein, so that uniform applications can be ensured with the solutions. aqueous cleaning and deodorizing agents as described herein.
    In another embodiment, the diameter of the tablet is between 0.3 and 3 cm, preferably 2 cm. In one embodiment, the weight of the tablet is between 1 and 10 g, preferably 4 g. Advantageously, tablets having the size as described herein can easily be dissolved in containers which are commonly used for spraying solution applications. In addition, the weight of the tablets ensures a solid dosage form having an appropriate concentration.
    In another embodiment, the tablet as described herein further comprises other compounds that enhance the incorporation of a liquid, preferably the fragrance, into the powder, such as a drier, preferably silica. smoke, such as Aerosil®. Preferably, these other products, such as drier, preferably fumed silica, are present at a concentration between 0.1 and 15% by weight, more preferably between 5 and 10% by weight. The inventors have discovered that these other compounds, such as a drier, preferably fumed silica, have a beneficial and beneficial effect on the physicochemical properties of the tablet as described herein and interact beneficially with the other components of the tablet. as described herein such that, for example, optimal dissolution, release of fragrances, etc. can be obtained.
    It should be understood that not only the specific combination of the ingredients in the solid dosage form as described herein (ie Bacillus subtilis, effervescent agent, surfactant, descaling agent, fragrance and optionally other compounds which improve the incorporation of a liquid such as fragrance, with a drying agent, especially fumed silica), is unprecedented. Also the specific concentrations of each of the ingredients, also relative to each other, are unprecedented and provide a solid dosage form with deodorizing and cleaning properties and with superior physicochemical properties, among which the ability to form a tablet compact.
    In another aspect, the invention relates to a method for preparing a deodorizing and cleaning solution, comprising the step of dissolving the tablet as described herein in water.
    In one embodiment, the invention relates to the method for deodorizing and cleaning as described herein, comprising the step of applying the tablet as described herein or the solution obtained by dissolving the tablet, such as described here, on or in an article to deodorize and clean.
    In another aspect, the invention relates to the use of the tablet, as described herein or the solution obtained by dissolving the tablet, as described herein for deodorizing and cleaning.
    In another aspect, the invention relates to a kit comprising the tablet, as described herein and a container for dissolving the tablet, in a sufficient amount of water to reconstitute a deodorizing and cleaning solution.
    Aspects and embodiments of the above and future invention are described in the following sections and in the appended claims. The subject of the appended claims is herein specifically incorporated in this specification.
    DETAILED DESCRIPTION OF THE INVENTION
    As used herein, the singular forms "one", "one" and "the" include both singular and plural references unless the context clearly indicates the opposite.
    The terms "comprising", "includes" and "composed of" as used herein are synonymous with "including", "includes" or "containing", "contains" and are inclusive or open and do not exclude additional components, elements or process steps not mentioned. It will be appreciated that the terms "comprising", "comprises" and "compound of" as used herein include the terms "consisting of", "consists" and "consists of", and the terms "consisting essentially of" , "Consists essentially" and "essentially consists of".
    The reference to extreme value ranges includes all numbers and fractions within the respective ranges, as well as the extreme values mentioned.
    The term "about" or "approximately" as used herein with reference to a measurable value such as a parameter, a quantity, a time duration and the like, is intended to encompass variations of +/- 20% or less, of preferably +/- 10% or less, more preferably +/- 5% or less, and still more preferably +/- 1% or less of and from the specified value, to the extent that such variations are appropriate to be realized in the disclosed invention. It should be understood that the value to which the "about" or "approximately" modifier refers is itself also specifically, and preferably, disclosed.
    While the terms "one or more" or "at least one", such as one or more or at least one component (s) of a group of components, are clear in themselves, by means of As an additional example, the term includes inter alia a reference to any one of said components, or to any one of two or more of said members, such as, for example, 3, 4, 5, 6 or £ 7 etc. of those members, and up to the totality of those members.
    Unless otherwise indicated, all terms used in the disclosure of the invention, including technical and scientific terms, have the meaning commonly accepted by those skilled in the art to whom this invention belongs. As additional guidelines, definitions of terms are included to better appreciate the teaching of the present invention.
    In the following passages, various aspects of the invention are defined in more detail. Each aspect thus defined can be associated with any other aspect or any other aspect unless otherwise indicated. In particular, any specificity indicated as being preferred or advantageous may be associated with any other specificity or any other specificity indicated as being preferred or advantageous.
    The reference throughout this "one embodiment" specification means that a specificity, structure or particular feature described in connection with an embodiment is included in at least one embodiment of the present invention. Thus, appearances of the terms "in one embodiment" or "in one embodiment" in various passages throughout this specification do not necessarily all refer to the same embodiment, but can. In addition, the particulars, structures or particular features may be combined in any suitable manner, as would be apparent to one skilled in the art from this disclosure, in one or more embodiments. Further, while some embodiments described herein include some but not the other features included in other embodiments, combinations of features of different embodiments are intended to be within the scope of the invention and form different embodiments, as will be understood by those skilled in the art. For example, in the appended claims, any of the claimed embodiments may be used in any combination.
    Described herein is a tablet for deodorizing and cleaning comprising: (i) one or more Bacillus subtilis strains; (ii) one or more surfactants; (iii) one or more fragrances; (iv) one or more descaling agents; and (v) one or more effervescent agents.
    Preferably the tablet comprises one or more strains of Bacillus subtilis. Those skilled in the art will understand that other bacterial strains may be used, preferably bacterial strains with the ability to form a resistant protective endospore, and preferably bacterial strains selected from the group consisting of Bacillus (subtilis, licheniformis, amyloliquefaciens, stearothermophylus, caldolyticus, pasteurii, laevolaticus, megaterium, sphaericus, firmus, clausii, cerus, velezenis, circulans, pumilus), Pseudomonas (fluorescens, putida), Arthrobacter, Lactic acid bacteria (Lactobacillus, Lactococcus), Alcaligenes, Enterobacter, Streptococcus, Rhizopus , Nitrosomas, Nitrobacter and / or Klebsiella, and preferably bacterial strains selected from the group consisting of Bacillus licheniformis, Bacillus circulans, Bacillus pumilus and / or Bacillus amyloliquefaciens.
    Preferably the tablet comprises one or more strains of Bacillus subtilis and one or more strains of Bacillus licheniformis, Bacillus circulans, Bacillus pumilus and / or Bacillus amyloliquefaciens.
    It should be understood that according to the invention, the constituents listed above are preferably combined and thus included in a single tablet.
    As used herein, the term "solid dosage form" refers to a solid composition comprising a plurality of individual components. The constituents in the solid dosage form are present in certain selected concentrations or amounts. It should be understood that according to the invention, the solid dosage form as described herein is to be reconstituted in water so that a liquid solution, preferably an aqueous solution, is obtained in which the individual constituents are present in certain reconstituted concentrations or quantities. Those skilled in the art will understand that depending on the amount of liquid in which the solid dosage form is reconstituted, more or less concentrated solutions can be obtained. The solid dosage form according to the invention is a tablet. The skilled person has extensive knowledge of tablet formation. For example, the tablets can be obtained by compression of the constituents. While the tablet as described herein contains the components (i) to (v) listed above, those skilled in the art will understand that the tablet may include additional components, which may or may not be active to deodorize and / or or clean. Examples of such additional components include diluents, fillers, binders or granulating agents, lubricants to aid compression, dyes, chelators, antimicrobial compounds, thickeners, driers, abrasives, anti-caking agents, water softeners, antiredeposition agents, odor neutralizing and / or masking agents, pH adjusting agents, etc.
    In one embodiment, the tablet according to the invention is a tablet having a cylindrical shape. In one embodiment, the tablet, preferably cylindrical, has a surface diameter between about 0.3 and 3 cm, such as 0.3, 0.5, 0.75, 1, 1.25, 1.5, 1.75, 2, 2.25, 2.5, 2.75 or 3 cm; preferably between about 1 and 2.5 cm, most preferably 2 cm or about 2 cm. The tablet may also have an irregular shape or volume or for example be also generally elongated with a polygonal surface. It will be understood that the enumerated dimensions, ie the surface diameter, can also be applied to such shapes. As used herein, the particular diameter of a polygonal surface refers to the maximum diameter.
    In one embodiment, the tablet according to the invention has a weight between about 1 and 10 grams, such as 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 grams; preferably between about 2 and 8 grams, more preferably between about 3 and 5 grams, most preferably 4 grams or about 4 grams.
    The tablet, as used herein, can be used for deodorization and cleaning. As used herein, "deodorization" refers to the reduction or elimination of unpleasant odors, i.e., smells typically considered to be offensive. As used herein, "cleaning" means the removal or partial or complete decomposition of unwanted substances on or in an article to be cleaned, such as in particular deposits of organic matter or tartar (calcium).
    The tablet according to the invention comprises at least one strain of Bacillus subtilis. Bacillus subtilis is a gram-negative rod-shaped bacterium with the ability to form a resistant protective endospore, allowing the body to tolerate extreme environmental conditions. The inventors have found that Bacillus subtilis is particularly suitable for incorporation into solid dosage forms as described herein. In a preferred embodiment, the Bacillus subtilis strains as described herein are present in the solid dosage form according to the invention as spores or endospores. It should be understood that the strain (s) of Bacillus subtilis according to the invention is (are) non-pathogenic. At least one Bacillus subtilis, preferably its (endo) spores, is present in the solid dosage form as described herein. It is known in the art that Bacillus subtilis produces and secretes numerous enzymes that are capable of enzymatically treating various compounds, including several compounds that cause or are associated with unpleasant odors. Preferably, the Bacillus subtilis strains as described herein are capable of producing and secreting one or more of the following enzymes: protease, esterase, cellulase, lipase, amylase, urease, or xylanase, preferably one or more of the protease, the cellulase, amylase and lipase, preferably all. In one embodiment, more than one strain of Bacillus subtilis can be provided in the solid dosage form as described herein, such as different Bacillus subtilis strains each producing one or more of the enzymes listed above. By way of example, and without limitation, commercially available Bacillus subtilis containing compositions such as the Genzyme (Genesis Biosciences) product line, eg Genzyme Mu, may be used. In addition, Bacillus subtilis strains that can be used include one or more Bacillus subtilis having accession number ATCC 202137, 202138, 202139, 6051 (see also US 6,140,106 and US 5,733,355 in this regard). . In one embodiment, the solid dosage form as described herein comprises one or more Bacillus subtilis strains, preferably (endo) spores, capable of expressing and / or secreting protease, esterase, cellulase. , lipase, amylase, urease or xylanase, preferably one or more of protease, cellulase, amylase and lipase, preferably all.
    Preferably, the one or more strains of Bacillus subtilis are present in the solid dosage form according to the invention in an amount between about 106 and 1011 cfu (colony-forming units), such as 106, 107, 108, 109, 1010, or 1011 cfu, preferably between about 10 and 1011 cfu, more preferably between about 109 and 1011 cfu. These quantities may relate to the total amounts for all the strains combined, but preferably these quantities relate to the quantities per strain. In a preferred embodiment, these amounts relate to quantities for tablets having the size and / or weight as previously described. Thus, in a preferred embodiment, the tablet according to the invention has a diameter between about 0.3 and 3 cm, a weight between about 1 and 10 grams and comprises between about 10® and 1011 cfu of each strain of Bacillus subtilis. . Those skilled in the art will understand that other bacterial strains may be used, preferably bacterial strains with the ability to form a resistant protective endospore, and preferably bacterial strains selected from the group consisting of Bacillus (subtilis, licheniformis, amyloliquefaciens, stearothermophylus, caldolyticus, pasteurii, laevolaticus, megaterium, sphaericus, firmus, clausii, cerus, velezenis, circulans, pumilus), Pseudomonas (fluorescens, putida), Arthrobacter, Lactic acid bacteria (Lactobacillus, Lactococcus), Alcaligenes, Enterobacter, Streptococcus, Rhizopus , Nitrosomas, Nitrobacter and / or Klebsiella, and preferably bacterial strains selected from the group consisting of Bacillus licheniformis, Bacillus circulans, Bacillus pumilus and / or Bacillus amyloliquefaciens.
    Preferably the tablet comprises one or more strains of Bacillus subtilis and one or more strains of Bacillus licheniformis, Bacillus circulans, Bacillus pumilus and / or Bacillus amyloliquefaciens.
    The tablet according to the invention further comprises at least one surfactant. Surfactants are well known in the art. As additional guidelines, as used herein, the surfactants are amphiphilic molecules, which means that they contain both hydrophobic groups (tails) and hydrophilic groups (heads). Therefore, a surfactant contains both a water-insoluble (or oil-soluble) component and a water-soluble component. As used herein, the surfactants may be detergents, wetting agents or dispersing agents. According to the invention, the surfactant may be any surfactant known in the art. In one embodiment, the surfactant is an anionic surfactant. Anionic surfactants contain anionic functional groups at their head, such as sulfate, sulfonate and carboxylates. In one embodiment, the surfactant is a sulfate, sulfonate or phosphate ester, preferably a sulfate ester. Preferably, the surfactant is an alkyl sulfate. In one embodiment, the surfactant is selected from the group consisting of or consisting of ammonium lauryl sulphate and sodium lauryl sulphate, most preferably sodium lauryl sulphate (also referred to as SDS, sodium dodecyl sulphate). In another embodiment, the surfactant is an alkyl ether sulfate, as selected from the group consisting of or consisting of sodium laureth sulfate (also known as sodium lauryl ether sulfate) and sodium myreth sulfate. In another embodiment, the surfactant is a docusate, such as sodium dioctylsulfosuccinate, perfluorooctane sulfonate (PFOS), perfluorobutane sulfonate, linear alkylbenzene sulfonates (LABS). In another embodiment, the surfactant is a carboxylate, such as alkyl carboxylates (soaps), for example sodium stearate, sodium lauroylsarcosinate and carboxylate fluorotensiatives such as perfluorononanoate, perfluorooctanoate ( PFOA or PFO). In another embodiment, the surfactant is a cationic surfactant whose charge may be pH dependent, such as primary, secondary or tertiary amines, for example octenidine dihydrochloride; or may comprise quaternary ammonium cations with a permanent charge, such as alkyltrimethylammonium salts, for example cetyltrimethylammonium bromide (CTAB) or cetyltrimethylammonium chloride (CTAC); cetylpyridinium chloride (CPC); benzalkonium chloride (BAC); benzethonium chloride (BZT); 5-bromo-5-nitro-1,3-dioxane; dimethyldioctadecylammonium chloride or dioctadecyldimethylammonium bromide (DODAB). In another embodiment, the surfactant is a zwitterionic surfactant (i.e., having cationic and anionic centers attached to the same molecule). The cationic part may be based on primary, secondary or tertiary amines or quaternary ammonium cations. The anionic moiety may be more variable and include sulfonates, as in CHAPS (3 - [(3-cholamidopropyl) dimethylammonio] -1-propanesulfonate). The other anionic groups are the sultaines illustrated by cocamidopropyl hydroxysultaine; betaines, for example cocamidopropyl betaine; phosphates, for example lecithin. In another embodiment, the surfactant may be a nonionic surfactant (i.e., not loaded). Many long chain alcohols have surfactant properties. The most important of these are the fatty alcohols cetyl alcohol, stearyl alcohol and cetostearyl alcohol (consisting predominantly of cetyl and stearyl alcohols) and oleyl alcohol. Examples of nonionic surfactants include polyoxyethylene glycol (Brij) alkyl ethers, such as octaethylene glycol monododecyl ether or pentaethylene glycol monododecyl ether; polyoxypropylene glycol alkyl ethers; glucoside alkyl ethers, such as decyl glucoside, lauryl glucoside or octyl glucoside; octylphenol ethers of polyoxyethylene glycol, such as Triton X-100; alkylphenol ethers of polyoxyethylene glycol, such as Nonoxynol-9; alkyl esters of glycerol, such as glyceryl laurate; alkyl esters of polyoxyethylene glycol-sorbitan (polysorbate); alkyl esters of sorbitan (Spans); cocamide monoethanolamine, cocamide diethanolamine; dodecyldimethylamine oxide; block copolymers of polyethylene glycol and polypropylene glycol: poloxamers; or polyethoxylated tallow amine (POEA).
    In one embodiment, the one or more surfactants are present in the tablet in a concentration between about 0.1 and 5% by weight, such as 0.1, 0.5, 1, 1.5, 2, 2, 5, 3, 3.5, 4, 4.5 or 5% by weight, preferably between about 1 and 5% by weight, more preferably between about 2 and 5% by weight, still more preferably between about 3 and 5% by weight, most preferably 4% by weight or about 4% by weight. These amounts may relate to the total amounts of all the surfactants combined or may relate to the amounts by surfactant.
    The tablet according to the invention also comprises at least one fragrance. As used herein, the term "fragrance" refers to an odorant or an aromatic compound or a mixture of odorants and aromatic compounds. The fragrance can be a fragrance. The term fragrance may also relate for example to plant extracts, such as essential oils, comprising one or more aromatic compounds. As used herein, the fragrance may be a natural fragrance or may be a synthetic fragrance. It is to be understood that a fragrance as herein understood means a compound or mixture of compounds commonly known to have a pleasant or pleasant odor as opposed to a bad odor. The fragrance according to the invention can be any type known in the art, such as for example and without limitation esters, linear or cyclic terpenes, aromatic compounds, alcohols, etc. In a preferred embodiment, the fragrance is based on mint, such as peppermint, i.e., the fragrance is based on one or more naturally occurring compounds in mint / peppermint. Preferably, the fragrance comprises in one or more of DL-menthol, delta p-mentha-1 (6), 8-dien-2-one, p-menthan-3-one and Rp-Mentha-1. , 8 diene. In one embodiment, the fragrance is an extract or essential oil of mint, such as peppermint.
    In one embodiment, the tablet according to the invention comprises between about 2 and 10% by weight of one or more fragrances, preferably a mint-based fragrance as previously described, such as 2, 3, 4, 5, 6. , 7, 8, 9 or 10% by weight, preferably between about 3 and 9% by weight, between 4 and 8% by weight, between 5 and 8% by weight, between 5 and 7% by weight, between 6 and 8% by weight or between 7 and 8% by weight. Preferably, the fragrance is present in an amount of 7% by weight or about 7% by weight. These quantities may relate to the total quantities for all the associated fragrances or may relate to the quantities by fragrance, which itself could be a mixture, such as an essential oil. In another embodiment, the fragrance as detailed herein is present in an amount of at least 5.5% by weight or between about 5.5 and 10% by weight, preferably between 5.5 and 9% by weight. weight, between 5.5 and 8% by weight or between 5.5 and 7% by weight.
    The tablet according to the invention further comprises at least one descaling agent. As used herein, the term "descaling agent" refers to a compound or a mixture of compounds that are intended to remove resistant deposits on surfaces, particularly calcium-containing deposits, but also deposits containing magnesium or aluminum. other deposits containing other metal cations. Accordingly, the term descaling agent also refers to a decalcifying agent. The descaling agents according to the invention are preferably acids, such as inorganic acids (for example nitric acid, hydrofluoric acid, sulfuric acid or hydrochloric acid) or organic acids (for example citric acid, glycolic acid or formic acid). The descaling agent (s) may form complexes or sequester cations, in particular metal cations. In one embodiment, the descaling agent is a chelator. The chelator can be a synthetic chelator (e.g. EDTA, EGTA, BAPTA) or can be a natural chelator. In a preferred embodiment, the descaling agent is an organic acid, preferably a weak organic acid. In one embodiment, the organic acid is selected from the group consisting of or consisting of citric acid, glycolic acid and formic acid. Preferably, the descaling agent is citric acid.
    In one embodiment, the tablet according to the invention comprises between about 1 and 60% of one or more descaling agents, preferably citric acid, such as 1, 5, 10, 15, 20, 25, 30, 35 , 40, 45, 50, 55 or 60% by weight, preferably between about 5 and 60% by weight, between about 10 and 60% by weight, between about 20 and 60% by weight, between about 30 and 60% by weight. weight, between about 40 and 60% by weight, between about 50 and 60% by weight, between about 5 and 50% by weight, between about 10 and 50% by weight, between about 20 and 50% by weight, between about 30 and 50% by weight. and 50% by weight, between about 40 and 50% by weight, between about 5 and 40% by weight, between about 5 and 30% by weight, between about 5 and 20% by weight, between about 5 and 10% by weight between about 10 and 40% by weight, between about 10 and 30% by weight, between about 10 and 20% by weight, between about 20 and 40% by weight, between about 20 and 30% by weight or between about 30 and 30% by weight. 40% by weight. Most preferably, the one or more descaling agents are present in an amount between about 20 and 30% by weight or between about 45 and 50% by weight. These amounts may relate to the total amounts for all descaling agents combined or may relate to quantities by descaling agent.
    The tablet according to the invention further comprises at least one effervescent agent. As used herein, the term effervescent agent refers to a compound or mixture of compounds that result in the generation and release of a gas upon administration into a liquid or once in contact with a liquid. Any effervescent agent known in the art can be used according to the invention. Preferably, the effervescent agent in the tablet according to the invention results in the generation and release of CO 2 when administered in a liquid medium, such as water. In one embodiment, the effervescent agent according to the invention comprises an acid and a carbonate salt (for example calcium carbonate) or a bicarbonate salt (for example sodium bicarbonate), preferably a metal salt, preferably an acid and baking soda, an organic acid and a carbonate salt or a bicarbonate salt or an organic acid and baking soda. Most preferably, the effervescent agent according to the invention comprises citric acid and sodium bicarbonate.
    In one embodiment, the tablet according to the invention comprises between about 40 and 95% by weight of one or more effervescent agents, preferably a mixture comprising citric acid and sodium bicarbonate, such as 40, 50, 60, 70, 80, 90 or 95% by weight, preferably between about 40 and 90% by weight, between about 40 and 80% by weight, between about 40 and 70% by weight, between about 40 and 60% by weight between about 40 and 50% by weight, between about 50 and 90% by weight, between about 50 and 80% by weight, between about 50 and 70% by weight, between about 50 and 60% by weight, between about 60 and 90% by weight, between about 60 and 80% by weight, between about 60 and 70% by weight, between about 70 and 90% by weight or between about 70 and 80% by weight, more preferably between about 60 and 70% by weight. weight, most preferably 65% by weight or about 65% by weight. These amounts may relate to the total amounts for all the effervescent agents combined or may relate to the amounts per effervescent agent. In the case of effervescent agents comprising a mixture of compounds, such as citric acid and sodium carbonate, the amounts preferably denote the combination of the two compounds. The relative ratios of individual compounds in such a mixture constituting the effervescent agent can be determined on the basis of stoichiometry as is well known in the art and taking into account the valence of the ions involved. As guidelines, for effervescent agents based on citric acid and sodium bicarbonate, equimolar amounts of the two components can be mixed.
    In one embodiment, the descaling agent as described herein may also have the function (as an element) of an effervescent agent as described herein. For example, an acid, such as an organic acid, for example citric acid, may have the function of a descaling agent and also in combination with a carbonate or bicarbonate salt, for example baking soda, as a effervescent agent. It will be understood by those skilled in the art that the concentrations and amounts of such dual function components as described herein can be adapted in such a situation. By way of example, and without limitation, if 20 to 25% by weight of sodium bicarbonate is used, an equimolar amount of citric acid can be used to reconstitute the effervescent agent and an additional 20 to 30% of citric acid can be used as a descaling agent. A tablet form according to the invention may therefore, by way of non-limiting example, comprise between approximately 40 and 55% by weight of citric acid. It will be understood that the same principles apply once the necessary changes have been made when using mixtures of more than one descaler / effervescent agent that may be interchangeable.
    In one embodiment, the tablet according to the invention comprises between 40 and 97% by weight of combined descaling agent and effervescent agent, such as 40, 41, 45, 50, 55, 60, 65, 70, 75 , 80, 85, 90, 95, 96 or 97% by weight, preferably between about 50 and 85% by weight, between about 55 and 80% by weight, 60 and 75% by weight or 65 and 75% by weight.
    In one embodiment, the tablet according to the invention comprises between about 1 and 60% by weight of one or more descaling agents, preferably citric acid, such as 1, 5, 10, 15, 20, 25, 30 , 35, 40, 45, 50, 55 or 60% by weight, preferably between about 5 and 60% by weight, between about 10 and 60% by weight, between about 20 and 60% by weight, between about 30 and 60 % by weight, between about 40 and 60% by weight, between about 50 and 60% by weight, between about 5 and 50% by weight, between about 10 and 50% by weight, between about 20 and 50% by weight, between about 30 and 50% by weight, between about 40 and 50% by weight, between about 5 and 40% by weight, between about 5 and 30% by weight, between about 5 and 20% by weight, between about 5 and 10% by weight, between about 10 and 40% by weight, between about 10 and 30% by weight, between about 10 and 20% by weight, between about 20 and 40% by weight, between about 20 and 30% by weight or between about 30 and 40% by weight; and further comprises between about 40 and 95% by weight of one or more effervescent agents, preferably a mixture comprising citric acid and sodium bicarbonate, such as 40, 50, 60, 70, 80, 90 or 95% by weight, preferably between about 40 and 90% by weight, between about 40 and 80% by weight, between about 40 and 70% by weight, between about 40 and 60% by weight, between about 40 and 50% by weight weight, between about 50 and 90% by weight, between about 50 and 80% by weight, between about 50 and 70% by weight, between about 50 and 60% by weight, between about 60 and 90% by weight, between about 60 and 80% by weight, between about 60 and 70% by weight, between about 70 and 90% by weight or between about 70 and 80% by weight, more preferably between about 60 and 70% by weight, most preferably 65% by weight. weight or about 65% by weight; the associated amount of descaling agent and effervescent agent not exceeding 97% by weight, more preferably not exceeding 95% by weight and preferably being between about 40 and 97% by weight of descaling agent and agent effervescent combined, such as 40, 41, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96 or 97% by weight, preferably between about 50 and 85% by weight, between about 55 and 80% by weight, 60 and 75% by weight or 65 and 75% by weight.
    In one embodiment, the descaling agent is one or more organic acids, preferably citric acid, and the effervescent agent is a mixture of these or one or more different organic acids that may also have the the function of a descaling agent, for example citric acid, and a carbonate or bicarbonate salt, for example sodium bicarbonate, the weight ratio of the organic acid (s) with the carbonate or bicarbonate salt being between about 4 and 1 and 1.1 to 1, preferably from about 3 to 1 to 1.5 to 1, most preferably from about 2.5 to 1 to 1.8 to 1.
    In another embodiment, the tablet as described herein further comprises other compounds that enhance the incorporation of a liquid, preferably the fragrance, into the powder, such as driers, preferably fumed silica, such as Aerosil®. Preferably, the fumed silica is present in a concentration of between 2 and 15% by weight, most preferably between 5 and 10% by weight, such as for example 5, 6, 7, 8, 9 or 10% by weight. Other compounds can also obtain the same results as zinc stearate (0.1 to 1% by weight), sorbitol (1 to 5% by weight), polyethylene glycol 6000 (0.1 to 1% by weight). ) and Tixosil (6 to 8% by weight).
    Tablet forms according to the invention comprise the constituents as listed in Tables 1 to 9 in the amounts indicated. The amounts are given in% by weight (for example 45 to 50 g of citric acid per 100 g of solid dosage form). Bacillus subtilis is given in cfu (colony forming units). It will be understood by those skilled in the art that the combined amounts of the individual components do not exceed 100%. When the combined amounts of the individual constituents are less than 100%, the remainder may consist for example of fillers, preferably inert fillers, additional excipients or active substances as previously described. In view of the interactions between the individual components, the concentrations of the components in Tables 1-8 have been found to provide optimum results in terms of cleaning and deodorizing efficiency.
    It will be appreciated that in addition to the essential components of the invention, as listed in Table 1, additional components may be added to the tablet according to the invention as indicated in Tables 2 to 8, and provide additional functions. or complementary.
    Table 1
    Table 2
    Table 3
    Table 4
    Table 5
    Table 6
    Table 7
    Table 8
    The fumed silica in each of Tables 1 to 8 can be replaced by any other compound that has improved the incorporation of a liquid, such as driers, especially fragrance, into a powder or other form of tablet. . Other compounds of this type include zinc stearate (preferably 0.1 to 1% by weight), sorbitol (preferably 1 to 5% by weight) and Tixosil (preferably 6 to 8% by weight). weight). Polyethylene glycol also has the same effect (preferably from 0.1 to 1% by weight).
    The fragrance in each of Tables 1 to 8 may in another embodiment also be present in an amount of 5.5 to 7% by weight. Particular advantages of such formulations include rapid dissolution combined with increased fragrance. These advantages are particularly evident in the formulations according to Tables 2 to 8.
    In another aspect, the invention relates to a method for preparing a deodorizing and cleaning solution, comprising the step of applying or dissolving the tablet as described herein in water, such as tap water. It will be understood by those skilled in the art that the solid dosage form as described herein is a concentrate that can be reconstituted by application or dissolution in water to obtain a dilute concentration of the individual components that can be used to clean and deodorize . Those skilled in the art will further understand that the amount of liquid in which the tablet as described herein may vary depending on the concentration of the components. In one embodiment, the tablet as described herein having the diameter and / or weight as described herein, and / or having the concentrations or amounts of the individual components as described herein, can be dissolved in 150. to 1500 ml of water, for example between 300 and 1200 ml of liquid, preferably between 650 and 1000 ml of liquid, such as for example 650, 700, 800, 900 or 1000 ml of liquid or approximately 650, 700, 800, 900 or 1000 ml of liquid, to reconstitute a cleaning solution and deodorization ready for use. It will be understood by those skilled in the art that, if necessary, more dilute or more concentrated reconstituted liquid cleaning and deodorizing solutions can be obtained by applying or dissolving the tablet as described herein in more or less water. or alternatively by applying or dissolving more or less of the tablet as described herein in a given amount of water.
    In one embodiment, the pH of the reconstituted cleaning and deodorizing solution is between about 3 and 6, preferably between about 3.5 and 5.5, more preferably between about 4 and 5, most preferably 4.5 or about 4.5.
    In another aspect, the invention relates to a method for deodorizing and cleaning, comprising the step of applying the tablet as described herein or the solution obtained by application or dissolution in water, as described above, on or in an article to deodorize or clean. In one embodiment, the invention relates to a method for deodorizing and cleaning an article containing a liquid by applying or dissolving the tablet as described herein in the article containing the liquid. By way of example, and without limitation, the article containing a liquid may be a toilet bowl, a septic tank, a liquid waste collector, etc. or associated evacuations or pipes. In another embodiment, the invention relates to a method for deodorizing and cleaning an article by applying the reconstituted cleaning and deodorizing solution as described herein to the surface of the article to be cleaned and deodorized. By way of example, and without limitation, such an article may be a wall, a window or a door, a workbench, a garbage bin or a waste collector, etc.
    In another aspect, the invention relates to the use of the tablet as described herein or the reconstituted solution as described above, for deodorizing and cleaning.
    According to another aspect, the invention relates to a kit comprising the tablet as described herein and a container for applying or dissolving the tablet as described herein in a sufficient amount of water, as detailed above, in order to reconstitute a solution of deodorization and cleaning. The size and shape of the container for reconstituting the cleaning and deodorizing solution are not of particular importance. In one embodiment, the container is a spray bottle, preferably a spray bottle of sufficient volume to reconstitute one or more tablet shapes as described herein as a liquid solution.
    EXAMPLES
    The composition of the solid dosage form according to the invention has been optimized. Three different formulations according to the invention were prepared and compared. The different formulations and the concentration of the individual constituents are listed in Table 9. The dissolution time, pH and perfume rating were evaluated. The results are shown in Table 10.
    Table 9
    As is clear from Table 10, the three formulations formed compact tablets.
    Table 10
    It was observed that for formulation 1, the dissolution time was longer than for formulations 2 and 3. For formulation 2, the odor of the perfume was lighter than for formulations 1 and 3. Formulation 3 represents an optimal formulation, which dissolved quickly and had a strong smell of perfume. In addition, the pH of formulation 3 was such that optimal descaling occurred.
    权利要求:
    Claims (16)
    [1]
    A deodorizing and cleaning tablet comprising: (i) one or more Bacillus subtilis strains; (ii) one or more surfactants; (iii) one or more fragrances; (iv) one or more descaling agents; and (v) one or more effervescent agents.
    [2]
    2. A tablet according to claim 1 comprising between 106 and 1011 cfu of said one or more Bacillus subtilis strains, preferably 109 cfu of said one or more Bacillus subtilis strains.
    [3]
    Tablet according to claim 1 or 2, wherein said one or more fragrances are based on mint, preferably on DL-menthol, delta p-mentha-1 (6), 8-dien-2-one, p-menthan-3-one and Rp-Mentha-1,8 diene.
    [4]
    4. Tablet according to any one of claims 1 to 3, comprising between 2 and 10% by weight of said one or more fragrances.
    [5]
    Tablet according to any one of claims 1 to 4, wherein said one or more surfactants are an alkyl sulfate, preferably sodium lauryl sulphate.
    [6]
    6. Tablet according to any one of claims 1 to 5, comprising between 0.1 and 5% by weight of said one or more surfactants.
    [7]
    Tablet according to any one of claims 1 to 6, wherein said one or more descaling agents are an organic acid, preferably citric acid.
    [8]
    8. Tablet according to any one of claims 1 to 7, comprising between 1 and 50% of said one or more descaling agents.
    [9]
    Tablet according to any one of claims 1 to 8, wherein said one or more effervescent agents are a mixture which releases carbon dioxide once in contact with water, preferably a mixture comprising citric acid. and baking soda.
    [10]
    Tablet according to any one of claims 1 to 9, comprising between 40 and 95% by weight of said one or more effervescent agents.
    [11]
    Tablet according to any one of claims 1 to 10, wherein the diameter of the tablet is between 0.3 and 3 cm, preferably 2 cm.
    [12]
    Tablet according to any one of claims 1 to 11, wherein the weight of the tablet is between 1 and 10 g, preferably 4 g.
    [13]
    A process for preparing a deodorizing and cleaning solution, comprising the step of dissolving the tablet according to any one of claims 1 to 12 in water.
    [14]
    14. A process for deodorizing and cleaning, comprising the step of applying the solution obtained according to claim 13 or a tablet according to any one of claims 1 to 12 to or in an article to be deodorized and cleaned.
    [15]
    15. Use of the tablet according to any one of claims 1 to 12 or the solution obtained according to claim 13 for deodorizing and cleaning.
    [16]
    16. Kit comprising the tablet according to any one of claims 1 to 12 and a container for dissolving the tablet according to any one of claims 1 to 12 in a sufficient amount of water to reconstitute a deodorizing solution and cleaning .
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    同族专利:
    公开号 | 公开日
    US20140213500A1|2014-07-31|
    US8940679B2|2015-01-27|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US13/750,095|US8940679B2|2013-01-25|2013-01-25|Cleaning and deodorizing compositions and methods|
    US13750095|2013-01-25|EP14152381.1A| EP2759590A1|2013-01-25|2014-01-24|Cleaning and deodorizing compositions and methods|
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